1. Primary immune deficiency disorders

2. Acquired immune suppression due to disease or treatment:

┬╖ Haematological malignancies, including leukaemia and lymphoma

┬╖ Any other malignancy on radiotherapy or chemotherapy

┬╖ On biological therapy

┬╖ On high or moderate doses of corticosteroids

┬╖ On any other immune modulating or suppressant drug like methotrexate, azathioprine, MMF, tacrolimus, cyclophosphamide

┬╖ Any transplant recipient

┬╖ Any condition which requires a long-term immunosuppressive treatments

3. Haematological conditions or other causes leading to asplenia or splenic dysfunction:

┬╖ Thalassemia major and intermedius,

┬╖ Hereditary spherocytosis

┬╖ Sickle cell disease

4. Endocrine disorders:

┬╖ Diabetes mellitus

┬╖ Addison’s disease

┬╖ Congenital Adrenal Hyperplasia

┬╖ Hypopituitary syndrome

┬╖ Other significant hormonal dysfunction

5. Chronic neuro-disability:

┬╖ Cerebral palsy

┬╖ Autism

┬╖ Epilepsy,

┬╖ Neuro-degenerative diseases

┬╖ Neuro-muscular disorders

6. Learning disabilities

┬╖ Down syndrome

┬╖ Severe or profound and multiple learning disabilities due to any aetiology

7. Any other significant genetic and/or metabolic abnormalities that affect a number of systems

8. Chronic heart disorders

┬╖ Unrepaired congenital heart diseases

┬╖ Repaired heart diseases with significant residual diseases or shunts

┬╖ Haemodynamically significant acquired heart diseases

9. Chronic respiratory disorders

┬╖ Poorly controlled asthma which requires long term oral steroids or a history of severe asthma which required an ICU care

┬╖ Cystic fibrosis

┬╖ Bronchopulmonary dysplasia

┬╖ Interstitial lung diseases

┬╖ Significant bronchiectasis due to any aetiology

┬╖ Pulmonary hypertension

10. Chronic kidney diseases and nephrotic syndrome on regular follow up

11. Chronic liver diseases

12. Chronic gastrointestinal disorders including inflammatory bowel disease